B. Braun Medical, Inc.'s Irvine facility produced approximately 350,000 gallons per day of WFI (Water For Injection) using seven vapor compression distillation units that were manufactured & installed in the early 1970's. Although the system continued to produce acceptable water quality based on ongoing daily testing, the +35 year old stills could no longer be cost-effectively repaired and needed to be replaced by newer, more reliable WFI generation equipment.

In addition, Irvine facility capacity increase plans necessitated a purified water system capable of supporting higher WFI demand. The stills had far outlasted their original life expectancy of 15-20 years and needed to be replaced by a robust, efficient generation system that complies with current GMP design standards and satisfies future production needs.

The ultimate goal of the Irvine WFI Storage & Generation System Upgrade Project was a robust, flexible, energy-efficient, GMP compliant, cost effective, automated purified water generation system that could quickly respond to changing production needs and future capacity expansion.

Specific scope components included:

  • City feedwater booster pump replacement (3 total).
  • Three (3) pretreatment trains consisting of carbon filtration, water softening, sanitization skid, and ancillary components.
  • Three (3) 6000 gph vapor compression stills.
  • Two (2) Storage Tanks (15k gallons each).
  • Interconnecting piping, pumps, heat exchangers.
  • All necessary instrumentation and controls for a fully automated system.
  • Arch/infrastructure/support utility modifications.
  • Relocation of existing maintenance support areas and Mens bathroom.
  • All required installation, commissioning & qualification activities/costs/permits/fees.
  • Upgrade of existing Reverse Osmosis system to ensure reliable sterilizer process supply.
  • The new generation & storage system would be interfaced with the existing WFI distribution system – no modifications or enhancements to the current piping system are included in this scope.
  • Existing brine pits were reused.

BIM Features

  • Proposal
  • Self Perform Work Detailing
  • Self Perform Work Tracking
  • MEP Coordination
  • 4D Sequencing
  • Constructability Analysis
  • Laser Scanning
  • Site Logistics Planning

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