Expanding Proton Therapy Market Demands Innovative, Collaborative Solutions
13 minute read
Smaller footprints, complex technology and smarter solutions define what it takes to construct the facilities redefining the future of cancer care.
13 minute read
This article is included in the Great Things: Issue 13 edition of the DPR Newsletter.
Rising cancer diagnoses, increased awareness of treatment options, higher levels of insurance reimbursement and major advances in facility design and delivery that have slashed capital costs as building footprints have shrunk and the technology inside them improved—those are just a few key trends driving a surge in the proton therapy facility market in recent years.
Expanding Expertise, For Your Next Build
DPR Construction has grown its expertise with the proton therapy market and is undertaking an increasing number of these projects as part of its diverse healthcare and technical building portfolio nationwide.
Currently, DPR has proton therapy facility projects either completed or in various stages of preconstruction and construction across the country, including sites in Charlotte, NC, Wallingford, CT, and Boca Raton, FL. The company is also serving in a preconstruction advisory role to a project in the San Francisco Bay Area.
Technological Advancements Fuel Market Growth
A convergence of factors is fueling this growth, perhaps none more critical than the technological advancements in the proton therapy equipment itself, which has helped to sharply bring down costs.
The earliest proton therapy facilities were at times massive, multi-gantry structures featuring complex, large-scale particle accelerators, cyclotrons and gantry equipment with highly specialized infrastructure to house them. The prohibitive first cost to design and construct these facilities limited market growth as owners grappled with how to make them economically viable.
Over the past two decades, proton therapy vendors were successful in creating much more compact and advanced equipment and systems that shrank the facility's footprint. The one- and two-room facilities that are more standard today are efficient, making access to state-of-the art technology and cancer care more affordable. This efficiency is reflected in reduced capital spend on equipment, building and operation of these facilities.
Coinciding with these technological advancements, cancer patients and the healthcare professionals who treat them have become better informed about the advantages of proton therapy versus traditional radiation and have advocated for greater access to the treatment option. As insurance reimbursement for proton therapy catches up to meet demand and as cancer diagnoses have steadily risen, healthcare owners have faced competitive pressures to offer proton therapy as another tool in their cancer treatment portfolio—and to make these alternative treatment options available closer to where patients live.
Proton therapy construction is particularly complex in terms of the concrete work, and the mechanical and electrical systems to keep the equipment running. These are not cookie cutter buildings. It is a place to leverage our experience and continuous improvement to drive speed to market and consistency in execution, and to help owners serve their communities.
Sean Ashcroft
Healthcare Core Market Co-Leader, DPR
A Needed Tool For Healthcare Owners
Peter Carbone, senior vice president for facility development with Proton International, is currently working with the DPR team overseeing construction of a standalone center in Wallingford, CT, for a tri-venture that includes Proton International, Hartford HealthCare and Yale New Haven Health System.
Carbone has been a key player in the proton facility market in the U.S. for nearly 20 years, since his company (formerly ProCure) developed its first facility in Oklahoma City in 2006. “Proton therapy is really another tool in the toolbox for the radiation oncologist, and it is a tool you need if you are going to be a high-end cancer treatment hospital,” he noted.
Major advances in associated technologies such as CT imaging, which models tumors prior to treatment and can now be done in hours rather than days, has also played a role in driving growth, according to Carbone. “Patients are getting more and more educated on it, and the (associated) technology has really 'caught up' with the proton therapy, making it much more successful.”
The Connecticut project represents DPR’s first for Proton International as well as the first proton therapy facility in that state. Currently patients in the Hartford/Yale region must travel three hours to Boston for the closest treatment.
The facility, designed and built around a single room Ion Beam Applications (IBA) proton system, includes a two-story, 30,000-sq.-ft. medical office building with a mass concrete proton bunker. While it is representative of today’s smaller facilities that are a “fraction of the overall cost and size than they used to be,” Carbone pointed out that the project planning and development can still take years, and design and construction of the facilities remains as complex as ever.
Another project that exemplifies this dynamic of a smaller size but high degree of complexity: the 16,200-sq.-ft., single treatment room proton therapy project at Baptist Health’s Eugene M. And Christine E. Lynn Cancer Institute at Boca Raton Regional Hospital.
DPR is constructing the relatively compact proton therapy addition on an equally compact site, but the project logistics and site access challenges are anything but small. The site is only accessible from a single side and the new building is connected to the entrance of an existing operational cancer center.
This April, the project team celebrated a major milestone with the successful installation of the facility’s $20 million, 55-ton cyclotron and 77-ton gantry by vendor IBA. The highly choreographed installation sequence required that both pieces of equipment be threaded through small roof openings with only an inch and a half of tolerance.
"Every element involved in preparing for this highly technical work must fit together perfectly," said Rudy Amato, who helps lead DPR’s efforts on proton therapy centers.
The scale of complexity is immense, from miles of electrical and low-voltage systems, safety monitoring equipment, cabling, and conduit embedded within mass concrete walls, to the process piping and mechanical systems that support both patient treatment and equipment operation.
Proton therapy projects demand precise planning and execution, but when done right from the start, teams can deliver efficiently and avoid costly rework.
Rudy Amato
Proton Therapy Facility Expert, DPR
Key Components to a Successful Proton Therapy Project
So, what are some of the critical components that are essential to successfully design, develop and deliver a proton therapy facility in today’s market? Some key success factors include:
- Picking the right team and early onboarding;
- Fostering a highly collaborative approach from start to finish;
- Leveraging each team member's unique strengths, knowledge base and capabilities, as well as the full spectrum of virtual design and construction (VDC) tools and prefabrication; and
- Pursuing a strategy of continuous improvement that builds on lessons learned and knowledge sharing to increase predictability, decrease risk and meet owners’ budget, schedule and quality goals.
“A GC’s ability to bring not only the construction subject matter experts to the table but also to bring their local market expertise and understanding of the client to the team is really valuable. They bring expertise in logistics and partnering processes, and their ability to use all the latest tools to deliver these projects in as collaborative a fashion as possible is key.”
Paula Williams, Principal, Stantec
The Right Team, Involved Early
Picking the right team is the critical first step in setting a project up for success.
A highly skilled AEC team will work early on with the owner to help them select the proton equipment vendor and to “right-size” their facility to meet community and patient needs.
On their current project in Connecticut, Proton International sought a CM that would bring an onsite project management team armed with strong technical construction expertise and mass concrete expertise, due to the extensive amount of technical concrete work involved.
“It’s not just having the right people; it’s the right mix of people, from the project manager to the superintendent to the project engineer,” Carbone said.
Paula Williams, principal with the global design firm Stantec, has worked with DPR teams on several proton therapy projects, including those currently underway in Connecticut and South Florida, among others. As a recognized leader in the design of proton therapy facilities for many years, Stantec has completed 19 operational proton therapy facilities in the U.S. and globally, with another dozen currently in design or construction.
“A GC’s ability to bring not only the construction subject matter experts to the table but also to bring their local market expertise and understanding of the client to the team is really valuable,” Williams commented. “They bring expertise in logistics and partnering processes, and their ability to use all the latest tools to deliver these projects in as collaborative a fashion as possible is key.”
Strong Design, Preconstruction
Engaging key team members early in the design and preconstruction process and employing every tool at their disposal to ensure constructability, to maximize planning, and to minimize changes or rework is another critical success factor for the proton therapy facility project.
One of the most important early decisions the owner must make is what vendor and system will be used in their facility, as the entirety of the facility’s design and construction revolves around this selection. The vendor is integrated into the team to provide critical input from day one.
“From both a design and a construction perspective, digesting and understanding the vendor’s interface document is critical to ensuring we avoid any scope gaps,” said Williams.
Bringing key trade partners on board in a design-assist capacity can be extremely helpful, Williams said. “To have the key trade partners on board to assist in the design decision making process and evaluation of systems really helps with budgeting, constructability and early coordination.” Early involvement can also help identify and mitigate supply chain issues and long lead items that could disrupt the schedule.
Successful preconstruction engagement sets the project up for a successful execution of work, Ashcroft added. “It is critical to help manage first cost versus final cost, to identify risks in the execution, being ready to accommodate any advances in technology that might come between the start of design and the facility turnover. You want to have some flexibility built into your plan.” He continued, “Making sure you are dialed in on what the vendor requirements are and what that looks like in the built environment is critical.”
“The negative of these projects getting smaller is you still have a lot of the same technology as you did in the four-or-five-room facilities, but you’re pushing it together. So, there are a lot of places where systems overlap more than they used to. BIM has really helped and is key to delivering these proton projects.”
Peter Carbone, Senior Vice President for Development, Proton International
High Levels of Collaboration
Collaboration is the heart of any successful cancer center facility, and perhaps no factor plays a bigger role in the success of proton therapy projects than a highly integrated team that works collaboratively from the earliest design phase until project closeout to deliver solutions.
One prime example of how a collaborative approach can help drive success is the now completed Carolinas Medical Center Levine Cancer Proton & Advanced Radiation Center project in Charlotte, NC.
This project added a state-of-the-art, 34,500-sq.-ft. addition that was the first in the Carolinas to offer proton therapy, gamma knife therapy and radiopharmaceutical treatments. It included a three-story proton vault accommodating a rotating proton gantry weighing 300,000 pounds, Gamma Knife, CT, clinical area, support spaces and a pedestrian bridge. Manufactured by Mevion, this is the world’s first gantry-mounted proton accelerator.
The project team’s collaborative approach helped shape design solutions, material sourcing and logistics strategies that maximized value and provided cost certainty amid a volatile market. Utilizing target value delivery and an integrated approach, the project team overcame major challenges including a complex site location intersecting two of the busiest roads in Charlotte.
The project’s unique, future-focused design allowed for flexibility in the building to grow both vertically and horizontally while also allowing for another vault to be added. Working collaboratively from start to finish, the team was able to ensure completion on time and within budget.
Leveraging Technology, Prefabrication
Leveraging all the VDC tools at their disposal, the most successful proton therapy project team will build on lessons learned from one project to the next and foster an environment of continuous improvement.
Developing a highly detailed BIM model is critical, given the technical complexities of ensuring all the systems and components embedded within the massive concrete structure are positioned in exactly the right location. The model offers a roadmap for the precise construction to be executed in the field, helping avoid mistakes and rework, according to Carbone.
“The negative of these projects getting smaller is you still have a lot of the same technology as you did in the four-or-five-room facilities, but you’re pushing it together,” he said. “So, there are a lot of places where systems overlap more than they used to. BIM has really helped and is key to delivering these proton projects.”
Early collaboration to develop the BIM model by the design team, CM/GC and key trade partners is also vital to project success, according to Williams. “The ability for us to collaborate with trade partners in the BIM model, when they are brought on during design, allows that coordination to happen early, which certainly helps us meet/beat the schedules,” she said. “The construction team can hit the ground running when the documents are fully done because they have already started to do their shop drawing level of detailing while the design team is just finishing up design.”
In addition to leveraging BIM, prefabrication can also play a role helping drive schedule efficiency on proton therapy projects, according to Ashcroft. He notes there are many opportunities for using prefab, depending on the size and scale of the project and the interest in it from the owner.
“It can be as simple as the electrician racking conduit banks that will end up being cast into the beam line lid. Or in areas where there is lot of repetitive work that would add weeks of tying rebar and threading conduit, instead you can fly in racks of conduits that have been prefabbed off site and just hoist them into place,” he said. “That can cut a ton of time in your pour sequence and in the make ready. That’s where the opportunities are for the GC team, trade partners, the design team and all the stakeholders to really find ways to be smarter and more efficient.”
The Push for Continuous Improvement
Whether it is tapping VDC tools, prefabrication, lessons learned from previous projects or other strategies, the team’s focus on how it can improve from project to project to work smarter and better is another success factor on proton therapy projects.
Looking ahead, Ashcroft thinks that a team’s ability to leverage more technology to achieve stakeholder buy-in on how the room is going to be set up ahead of time will be crucial. That includes 3D Modeling, BIM coordination, and AR and VR, but he also calls out field technologies like point clouds and scanning to complement prefabrication approaches.
“We’re looking to use technology and tools to do it better, share lessons learned, and importantly, drive cost confidence with our trades so they are not pricing uncertainty into their numbers,” he said. “All these things come together to help us achieve success for the owner and the entire team.”
The Evolution of a Highly Complex Facility
A highly advanced form of radiation treatment, proton therapy has been heralded for its more precise, targeted approach that causes fewer side effects and secondary impacts to patients than conventional radiation therapy. It treats cancer tumors with controlled radiation produced from protons generated by a cyclotron inside a mass concrete bunker deep within the facility.
Proton therapy has been around for well over half a century, although it was initially slow to catch on. Lawrence Berkeley National Laboratory conducted the first experimental proton therapy treatment on a patient in 1954. Thirty-six years later, in 1990, Loma Linda University Cancer Center opened the first hospital-based proton therapy facility in the United States. It stood as the only one of its kind until 2001.
By 2005, there were a total of four proton therapy facilities in the U.S. In the two decades since, that number has grown to 45 facilities nationwide and counting, with many more projects currently in design, development and construction. These range from brand new stand-alone facilities to additions and/or renovations to existing facilities, as well as repurposing projects.
A recent market report by Business Wire projects that the U.S. proton therapy market, which it valued at just over $1 billion in 2024, will hit approximately $2.5 billion by 2033, increasing at a compound annual growth rate of 12% between 2025 to 2033.
Posted on August 7, 2025
Last Updated August 6, 2025
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